Medications in this class include:
- Spironolactone (Aldactone®)
- Eplerenone (Inspra®)
How do Aldosterone Antagonist work?
Aldosterone antagonists block hormones that put stress on your heart. They are also a diuretic, so they make your kidneys get rid of extra fluid. Aldosterone Antagonists have been shown in studies to make people with heart failure live longer and feel better.
How this medication should be taken:
- Take this medication at the same time(s) every day.
The most common side effects include:
- Feeling fatigued. This should improve as your body gets used to the medication.
- Increased potassium and worsening kidney function. This will be monitored with blood tests.
- Breast enlargement or tenderness in men (especially with Spironolactone).
- Passing more urine.
- Stomach cramps or diarrhea. You can take it with food to avoid an upset stomach.
- Nausea and vomiting.
What should I remember while taking this medication?
- This medication may be taken with or without food, but should be taken at the same time(s) each day.
- Use cautiously if you have certain types of kidney problems (check with your health care provider).
- Tell your health care provider or pharmacist of any prescription and non-prescription medications you are taking.
- Check with your health care provider before using potassium supplements (you may require extra blood tests to measure the amount of potassium in your blood).
- If you develop another illness and are not able to eat or drink, or if you have a lot of vomiting or diarrhea, contact your health care provider or pharmacist. Extra blood tests may need to be done to check your potassium level. In some cases, the medication may need to be held for a few days until you are feeling better. Do not stop any of your medications without speaking to your health care provider.
What should I do if I miss a dose?
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed. Take the next dose at the regular time. Do not take two doses at the same time. If you are unsure of what to do, speak to your health care provider or pharmacist.